From SCAN to SPARK: Galaxy Brain Scientific Enables a New Paradigm in Non-invasive, Personalized Precision Treatment for Parkinson's Disease

BEIJING, March 24, 2026 /PRNewswire/ -- A research team led by Prof. Hesheng Liu, founder and Chief Scientific Officer of Galaxy Brain Scientific Inc., has published a study in Nature Neuroscience demonstrating that Deep Brain Stimulation (DBS) achieves therapeutic efficacy in Parkinson's disease (PD) by remodeling the SPARK circuit. (https://www.nature.com/articles/s41593-026-02228-w)

The findings build directly on the team's previous identification of a core cortico-subcortical PD circuit derived from the somato-cognitive action network (SCAN), the SPARK (SCAN-Parkinson's) circuit, as reported in their study published in Nature in February 2026 (https://doi.org/10.1038/s41586-025-10059-1), which first characterized this circuit in PD. These results provide mechanistic evidence that neuromodulation therapies exert their effects through modulation of this circuit, and offer a circuit-level framework for the development of personalized, non-invasive precision treatment strategies.